Structural proteomics boost

Magnetic boost for structural studies

Researchers will soon be jostling for access to a new generation of NMR spectrometers allowing analysis of ever larger proteins, reports Michael Gross A shiny UFO has landed a few miles from Oxford, and rolled out a spiral staircase. That's at least what you might be forgiven for thinking when you see the latest product of Oxford Instruments: an NMR magnet muscling up to 21.1 tesla, correspondi...

Computational structural proteomics.

Structural Proteomics by NMR

Nuclear magnetic resonance (NMR) is a powerful spectroscopic technique that permits the detailed study at atomic resolution of the three-dimensional structure and dynamics of macromolecules and their complexes in solution. In this brief chapter, I discuss various aspects of NMR that are pertinent to structural proteomics, that is, the high-throughput study of protein–protein complexes at the at...

Structural Proteomics of Herpesviruses.

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have been unsuccessful because these viruses have developed numerous immune evasion mechanisms. Therefore, a better understanding of their complex lifecycle is needed. In particular, while the genome o...

NMR in the SPINE Structural Proteomics project.

This paper describes the developments, role and contributions of the NMR spectroscopy groups in the Structural Proteomics In Europe (SPINE) consortium. Focusing on the development of high-throughput (HTP) pipelines for NMR structure determinations of proteins, all aspects from sample preparation, data acquisition, data processing, data analysis to structure determination have been improved with...